A Detailed Analysis Of Alzheimer's Disease Pathophysiology: The Influence Of Oxidative Stress On Amyloid Precursor Protein Metabolism And Secretase Activity
Year: 2024
Type: article
Abstract: Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by cognitive decline, memory impairment, and distinct neuropathological features such as amyloid-beta (Aβ) plaques and neurofibrillary tangles. Despite extensive research, the molecular mechanisms underlying AD remain incompletely understood, posing challenges for therapeutic intervention. This review delves into the intricate processes of amyloid precursor protein (APP) processing, focusing on the roles of α-, β-, and γ-secretases in the generation of neurotoxic Aβ peptides. We explore the genetic and molecular insights into APP, emphasizing the significance of secretase-mediated cleavage and its regulation by oxidative stress, cholesterol, and mitochondrial dysfunction. The interaction between these pathological pathways offers a broader understanding of AD progression, highlighting potential targets for therapeutic strategies aimed at modulating APP processing and reducing Aβ burden.
Author: Manav Kumar 1, Alok Kumar1, Kajal Kumari1, Priyanka Kumari1, Shweta Kumari1, Divya Roshni Panna1, Suman Kumari1, Bina Kumari1, Sapna Kumari1, Anuradha Kumari1, Asfaque Ali1, Najibullah Mujahid 1, Laxman Kumar Mahto1, Maheshwar Kumar1, Saurav Kumar1, Ved Prakash Singh1, Soyab Akhtar1, Arnab Roy2*
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6911700067
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