Basic Pharmacology of New Oral Anticoagulants and Its Clinical Profile: an Incisive Review
Year: 2024
Type: article
Abstract: The direct oral anticoagulants (DOACs) or novel oral anticoagulants (NOACs) are the non-vitamin K antagonist anticoagulants, which are relatively newer in the market. They include oral direct thrombin and factor X inhibitors. The approved indications are stroke prevention, treatment and prevention of venous thromboembolism, and coronary artery disease treatment. Although, recent studies have showed that the NOACs have better safety profile, convenient to administer, and less food and drug interactions compared to current oral anticoagulants. Clinicians prefer to prescribe traditional oral anticoagulants such as warfarin in the clinical setting. Thus, the aim of this review is to discuss the pharmacological properties of DOACs, efficacy and safety profile, laboratorymonitoring tests, and current reversal agents, focusing on the latest evidence from the subclinical and clinical trials.
Author: Hanan Hassen Elsumd
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6911711102
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