Year: 2024
Type: article
Abstract: Background: HENOCH-Schoenlein purpura (HSP) is a multisystem disorder affecting predominantly the skin, joints, gastrointestinal tract and kidneys, although involvement of other organs can occur rarely. It is one of the most common causes of immunoglobulin A (IgA) mediated systemic small vessel vasculitis with IgA deposition in vessel walls leading to symptoms involving the skin, joints, intestines, and kidneys in children the world-over. Methods: This hospital based descriptive study was conducted at a major tertiary care teaching hospital in North India. All children were diagnosed as HSP, according to the 2010 European League against Rheumatism criteria7, admitted at various wards in the Department of Paediatrics, during the period of six months from June 2021 to December 2021 were included in the study. Results: In this study, 65 patients were included. The mean age at presentation was 6.5 years (Range 2 to 12 years). There were 40 boys and 25 girls with a male preponderance (male to female ratio 1.6:1). The common presenting symptoms were purpuric rash (n=65,100 %) , pain abdomen (n=42,64%), and arthritis (n=28,44), vomiting (n= 16,24%), Malena (n=3,5%), genitourinary symptoms like hematuria (n=3,4%), scrotal pain(n=4,6%), oedema(n=10,15%), hypertension(n=20,30%) were seen .In the laboratory parameters An elevated ESR (n=31,48%), anaemia(n=33,50%) , leucocytosis seen in 5 cases (18%), thrombocytosis in 13 (20%) patients . ASO titre of >200 was found in 10 (15%) patients. Abnormal urine analysis in 10 (15%) patients. Rheumatoid factor was positive in 17(4%) also stool for occult was positive in 12(19%) cases. Conclusion: The clinical features of Henoch Schonlein purpura in the population were different from the previously published studies. Renal involvement was less common the occurrence of life-threatening complications in HSP is very rare
Authors: Priyanka Sharma, Ravinder Gupta, Sakshi Sahni
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6911767131
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