A Formulation and Evaluation of Mefenamic Acid Emulgel Using Natural Permeation Enhancers
Year: 2024
Type: article
Abstract: Eumgel Mefenamic Acid is a topical gel formulation of Mefenamic Acid, a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat pain, inflammation, and fever. This formulation is designed to provide localized pain relief with minimal systemic side effects. The gel is absorbed through the skin, delivering the active ingredient directly to the site of pain, thereby enhancing the therapeutic effect while reducing the risks typically associated with oral NSAIDs, such as gastrointestinal irritation or systemic toxicity. Mefenamic acid in Eumgel works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2, leading to reduced production of prostaglandins, which are responsible for pain and inflammation. The Eumgel formulation offers a controlled release of Mefenamic Acid, ensuring effective and prolonged relief. Eumgel Mefenamic Acid is especially beneficial for the management of musculoskeletal pain, joint pain, and mild to moderate localized inflammation, including conditions like arthritis, sports injuries, and back pain. Clinical studies have demonstrated the safety and efficacy of Eumgel Mefenamic Acid for topical pain management, with patients experiencing significant pain reduction and improved mobility. The formulation's non-greasy and fast-absorbing nature makes it a convenient alternative to oral NSAIDs, providing an effective solution for pain management without the discomfort of traditional oral medications.
Author: Dajee Hulage*, Someshwar More, Dr. V. M. Satpute, Mr. Ghodake S. R.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6911809333
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