Adverse Drug Reaction Pattern to Commonly used Antibiotics in a Tertiary Care Hospital: A Prospective Observational Study
Year: 2024
Type: article
Abstract: Background: Drugs play a significant role in prophylaxis, diagnosis, and treatment of each and every disease. They are beneficial to the patients at the same time; they also result in unwanted and harmful effects which are called adverse drug reactions (ADRs). The aim of this study was to evaluate and analyse adverse drug reactions to antibiotics in patients of a tertiary care hospital at Bhagalpur, Bihar. Methods: This prospective observational study was carried out in Department of Pharmacology, Jawaharlal Nehru Medical College and Hospital, Bhagalpur, Bihar from January 2022 to December 2022. Patients were collected from various department of OPD and hospital ward of JLNMCH, Bhagalpur, Bihar. Results: A total number of 138 ADRs were selected during this study period. 98 were males and 40 were females. Maximum number of patients were from General Medicine department followed by General Surgery followed by Dermatology. Most of the reactions were mild (77.4%). Gastrointestinal system was the most commonly affected organ. In majority of the ADRs the suspected drug was withdrawn (60.8%). The association between a drug and ADR was evaluated using the Naranjo scale. In order to prevent or reduce harm to patients and thus improve public health, mechanisms for evaluating and monitoring public health, evaluating and monitoring the safety of medicines in medical use are vital. Conclusion: Antibiotics are most commonly prescribed drugs so its monitoring regarding ADRs may benefit the clinicians in early identification and management of ADRs so that quality of life of patient can be safeguarded at an earliest.
Authors: Ranjit Debbarma, Mrigendra Kumar, Jeetendra Kumar
Language: English
Subfield: Toxicology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6911809549
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