The Role of Standard Cytegenetic Testing in the Diagnosis of Acute Myeloid Leukemia.
Year: 2024
Type: article
Abstract: Acute myeloid leukemia (AML) is a clonal malignant disease characterized by ineffective hematopoiesis . Most patients with AML have various cytogenetic and molecular genetic lesions that are combined with certain biological and clinical features of the disease . Approximately 50–60% of patients de new and 80–95% of patients with secondary AML have chromosomal changes. It should be noted that structural cytogenetic aberrations are the most common markers and occur in approximately 40% of AML cases de novo . A fairly large group of patients with a normal karyotype (NC-AML), formally classified as intermediate risk, is extremely heterogeneous in terms of prognosis of the disease course. The current prognostic classifications of AML today include only some mutations characterized by a known prognostic value, in particular t (8 ; 21) , NPM 1 and BRAF.
Author: Musashaykhova, Shahnoza
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6911817373
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