Work

In silico Binding Prediction of Mitragyna speciosa Alkaloids to Human Opioid Receptors

Year: 2024

Type: article

Abstract: Kratom (Mitragyna speciosa), a tropical tree native to Southeast Asia, is traditionally used for its stimulant and sedative effects, which vary with dosage. The primary alkaloids, mitragynine, and 7-hydroxymitragynine, are known for their significant pharmacological activities, especially in pain management, making kratom a subject of growing scientific interest and legal debate. This study aims to bridge knowledge gaps by investigating the interactions of 35 distinct kratom alkaloids with the human mu (MOR), delta (DOR), and kappa (KOR) opioid receptors. These receptors are crucial in modulating pain, mood, and addictive behaviors. Using molecular docking, the binding affinities and receptor selectivity of these alkaloids were explored, shedding light on their pharmacological potential. The aim is to identify the promising kratom alkaloids for the future development of better drugs for pain management and disease treatments.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.13325013

Authors: Norazizi, Nur Balqis Nasuha, Ab Razak, Nurul Suhada, Jusoh, Siti Azma

Institutions: Universiti Malaysia Terengganu, Universiti Teknologi MARA System, Universiti Teknologi MARA

Language: English

Topic: Alkaloids: synthesis and pharmacology

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6911822788

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