Review on Targated Drug Delivery System
Year: 2024
Type: article
Abstract: Innovative drug delivery systems target disease or tissue directly, transforming treatment methods. These systems employ different tactics to surpass biological obstacles, aiming for accurate targeting and enhancing therapeutic effectiveness while reducing systemic side effects. Currently, 95 percent of newly developed drugs exhibit inadequate pharmacokinetic and biopharmaceutical characteristics. Therefore, it is necessary to create an appropriate drug delivery system that targets the therapeutically active drug molecule specifically to the intended site of action, while avoiding harm to healthy tissue or organs. When considering drug carrier soluble polymers, one can think about microparticles composed of insoluble or biodegradable natural and synthetic polymers, microcapsules, cells, cell ghosts, neutrophils, fibroblasts, artificial cells, lipoproteins, liposomes, micelles, immune micelle, and monoclonal antibodies. Targeted drug delivery is a sophisticated technique that efficiently delivers drugs to specific areas of the body, enhancing treatment effectiveness by concentrating the medication in the desired organs/tissues/cells and minimizing potential side effects. In essence, targeted drug delivery aims to help the drug molecule reach the intended site more effectively. Drug delivery using nanotechnology will lead to the drug remaining in the bloodstream for a longer period, resulting in decreased fluctuations in plasma levels and consequently, reduced side effects. Other methods also encompass polymer-drug conjugates and nanoscale systems like liposomes, quantum dots, dendrimers, and more. Various other strategies exist too.
Author: Ubale Kiran*, Pratik Bhanage, Dr. Megha Salve
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6911824641
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