Two-step One-Pot Multicomponent Reaction Improved by TBAF for the Preparation of 2-Amino-3, 5-dicyano-4-aryl-6-phenylsulfanylpyridines
Year: 2024
Type: article
Abstract: : To further explore TBAF's catalytic properties, a study investigated its role in the synthesis of 2-amino-3, 5-dicyano-4-aryl-6-sulfanyl-pyridines under mild conditions. Two-step One-Pot Multi-component reaction (MCR) synthesis of pyridines derivatives using TBAF as the catalyst was conducted across different organic solvents. The formation of 1a was observed in polar solvents like methanol, acetonitrile, dimethylformamide (DMF), and ethanol, with ethanol yielding the highest yield (91%). Notably, the absence of TBAF led to no product formation even after extended reaction times.
Authors: Anantwad, Santosh A., Suryawanshi, Amol R., Sayyed, Prof.Hussain
Institution: Dr. Babasaheb Ambedkar Marathwada University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6911826295
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