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Acute interstitial lung disease revealing dermatomyositis: Case study and analysis of diagnostic challenges

Year: 2024

Type: article

Abstract: Dermatomyositis (DM) is a rare, heterogeneous autoimmune disease of unknown cause, characterised by non-infectious inflammatory involvement of the muscles and skin associated with vasculopathy. It is also associated with visceral manifestations, particularly of the lungs. Various respiratory manifestations, sometimes combined, may be observed in DM, including involvement of the aerodigestive tract, involvement of the respiratory muscles and diffuse interstitial pneumonitis (DIP). Diffuse interstitial lung disease (DIL) is common and can be acute in onset, and is often associated with a specific class of myositis autoantibodies, including anti-MDA-5 antibodies, which are associated with a particular phenotype of DM, in which muscle involvement is minimal or absent but the risk of rapidly progressive interstitial lung disease is particularly high. We report a case of rapidly progressive acute diffuse interstitial lung disease revealing amyopathic dermatomyositis characterised by the presence of anti-MDA-5 autoantibodies.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.14958816

Authors: Maryem Hindi, Lina Romane, Hasna Yassine, Mohamed Ijim, Oussama Fikri, Lamyae Amro

Institutions: Cadi Ayyad University, Centre Hospitalier Universitaire Mohammed VI

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6911836720

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