Inhibition of the neddylation E2 enzyme UBE2M in macrophages protects against E. coli-induced sepsis
Year: 2024
Type: article
Abstract: Title:Transcriptome analysis of LPS-stimulated peritoneal macrophages from UBE2M knockout mice Description:This dataset contains RNA-sequencing data from a study investigating the role of UBE2M in macrophage inflammatory responses. The experiment compared transcriptional profiles between wild-type and UBE2M knockout peritoneal macrophages (PMs) following LPS stimulation. Experimental Design:- Mouse Model: UBE2M conditional knockout using LysM-Cre system- Cell Type: Peritoneal macrophages (PMs)- Treatment: Lipopolysaccharide (LPS)- Groups: * Wild-type + LPS (WL1, WL2, WL3; three biological replicates) * UBE2M knockout + LPS (KL1, KL2, KL3; three biological replicates) Data Description:The dataset includes:1. Gene expression matrix containing counts for all detected genes Data Format:- Expression matrix: .csv- Gene IDs: Ensembl gene identifiers with corresponding gene symbols- Expression values: [Counts]
Author: Wen, Xuehuan
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6911925247
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