Current Approaches in Endometrial Cancer: a Review
Year: 2025
Type: article
Abstract: Endometrial carcinoma (EC) is increasingly stratified by molecular and immunohistochemical (IHC) features that state the prognosis and guide the personalized therapy. Histopathologically, IHC surrogates for TCGA‑defined subtypes (POLE-mutated, MMR- deficient, p53‑abnormal and NSMP) stratify the risk in EC. Additional markers (ER, PR, and Ki‑67) further tailor management. Epithelial-mesenchymal transition (EMT) correlates with the myometrial invasion and metastasis. Hypoxia, via HIF‑1-α overexpression, promotes angiogenesis and stem‑like phenotypes in EC, detectable by IHC and linked to poor outcome. ARID-1A loss identifies a subset with distinct biological behaviour and potential sensitivity to epigenetic therapies. Integrating these markers into routine pathology practice will improve the precise personalized medicine.
Author: Markov D.
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6911941609
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