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Colorectal Adenocarcinoma in Precision Medicine

Year: 2025

Type: article

Abstract: This review discusses colorectal adenocarcinoma, one of the most common cancers worldwide, with increasing diagnoses and high mortality rates despite therapeutic advancements. Precision medicine plays a crucial role in treatment, with a focus on genetic mutations such as KRAS, NRAS, and BRAF, and microsatellite instability. Targeted therapies and immune checkpoint inhibitors are tailored based on the tumor's molecular profile, significantly improving survival rates. Trifluridine/tipiracil, regorafenib, and fruquintinib are effective in advanced stages, though with limited response rates. The importance of genomics and personalized treatment is emphasized, with biomarkers like KRASG12 mutations affecting overall survival outcomes.

Source: IRIS Research product catalog (Sapienza University of Rome)

DOI: 10.5281/zenodo.14901271

Author: Virginia A. Cirolla

Language: English

Topic: Colorectal Cancer Treatments and Studies

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6911947836

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