Formulation Development And Evaluation Of Mentha Spicata Leaf Powder Orodispersible Tablet
Year: 2024
Type: article
Abstract: This research was focuses on the formulation development and evaluation of Oro-dispersible tablets (ODTs) containing Mentha spicata leaf powder, aiming to explore its potential as a novel herbal formulation for oral administration. Mentha spicata, commonly known as spearmint, possesses various pharmacological properties, including antimicrobial, antioxidant, and anti-inflammatory effects, which make it a promising candidate for pharmaceutical applications. The formulation process involves the wet granulation method for Mentha spicata leaf powder tablet. The Tablet was evaluated for its physical, chemical, and mechanical properties, including tablet hardness, friability, disintegration time, and drug content uniformity. In vitro dissolution studies are conducted to investigate the release profile of bioactive constituents from the tablets. The In vitro release of the tablet was found to be in the range of 75.23±0.14% to 99.67±0.23%. Also, the comparative dispersion and disintegration time study of tablet has been carried out and was found to be 07.89±0.04 min and 12.04± 0.02 min respectively. From the stability study it was observed that, optimized formulations F4 were Stable at 40°C / 75%, 8°C in Refrigerator or 60°C in Incubator. The formulated ODTs offer the advantages of convenience, rapid disintegration, and improved patient compliance, making them suitable for various oral administration scenarios, including paediatric, geriatric, and dysphagic patients. Additionally, the potential pharmacological benefits of Mentha spicata make these ODTs promising candidates for the management of oral diseases, respiratory conditions, and other ailments requiring localized drug delivery via the oral mucosa.
Author: Pratiksha Jagtap, Vaibhav Changediya
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6911966752
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