Inclusion Complexes Is the Modern & Effective Technique of Encapsulation an Overview
Year: 2025
Type: article
Abstract: Only when oral medications exhibit high bioavailability and reasonable solubility in the gastric media can they fully absorb when taken orally. Drug solubility and dissolving characteristics are crucial to the formulation development process. One of the biggest problems facing formulation scientists is the solubility problem, which may be resolved using a variety of technical strategies when developing new pharmaceutical products. Micronization, solvent deposition, and solid dispersion are a few crucial techniques frequently used to improve the solubility of medications that are poorly soluble in water. Every strategy has its benefits and drawbacks. All things considered, the complexation process has been used more specifically to increase the aqueous solubility, dissolution rate, and bioavailability of medications that are not very water soluble. The special cyclic carbohydrates known as cyclodextrins have been effectively employed as possible complexing agents to create inclusion complexes with insoluble pharmaceuticals. A thorough review of the literature was conducted to gather evidence for the appropriate use of cyclodextrins as complexing agents and permeability enhancers. Diverse methodologies have been examined to elucidate the procedures involved in inclusion complex preparation. A survey of several complexation procedures was attempted, along with a brief discussion of their possible uses and related technical and financial limits.
Author: Gajare Akshay*, Lamkhade G. J., Dr Bhalekar S. M.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6911969733
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