Formulation and Characterization of Osmotic Tablets for Colon-specific Drug Delivery System
Year: 2024
Type: dissertation
Abstract: The present study aimed to prepare and evaluate an osmotic drug delivery system for the controlled release of glipizide for the treatment of type II noninsulin-dependent diabetes mellitus. To make bi-layer push-pull osmotic tablets, PEO was used as an expansion agent. Tablets were coated with Opadry CA and mechanically drilled. By changing the percentage of sodium chloride in the push layer, Preparations F10 and F11 were prepared to prevent the drug's initial delayed release. The drug release was accelerated by increasing the sodium chloride concentration, and the release profile resembled that of the innovator. When compared to the innovator, preparations F12 and F13 with 8% and 10% of release displayed quick release, while design F14 with 12% of release showed equivalent release. When related to the innovator, the relative release profiles of preparations with 12% and 14% exhibited a like release outline. However, 12% was decided upon as the optimized mass increase when linked to additional preparations, ultimate F14 as the improved preparation, and conducting additional research to scale up preparations. For three months, stability investigations were carried out at 40 ºC and 75% RH. The optimized preparation F14 was found to be stable and to comply with the Innovator product in terms of appearance, assay, and dissolving profile. Keywords: Glipizide, Osmotic drug delivery system, Polyethylene glycol, Opadry CA, Stability.
Author: G.Divya, D. Raj Kumar
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6912062960
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