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Synthesis and in vitro Evaluation of Novel Thiophene Derivatives

Year: 2025

Type: article

Abstract: sulfur-containing heterocycles used to create a wide variety of sophisticated compounds with a wide range of biological functions, they are valuable analogs for medicinal chemists. Synthesis novel thiophene derivative by Schiff base were validated by FTIR, MS and 1H-NMR. The produced compounds were additionally assessed for their in vitro biological potentials, specifically antimicrobial activity against chosen microbial species utilizing tube dilution method. Antimicrobial screening outcomes revealed that compound S1 emerged as the most effective antibacterial agent against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Salmonella typhi, with an MIC value of 0. 87 µM/ml.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.15478485

Author: Aditi Rajendra Late*, Kadam Vaibhav N., Dr. Rahane Rahulkumar D.

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6912155283

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