Next-generation Biohybrid Nanorobots Powered by Enzyme-driven Propulsion for Precision Drug Delivery in Tumor Microenvironments
Year: 2025
Type: article
Abstract: Recent advances in nanomedicine have enabled the development of next-generation therapeutic systems that possess autonomous navigation capabilities and real-time responsiveness to tumor microenvironments. Among these, biohybrid nanorobots—constructed by integrating synthetic nanoparticles with biological elements such as enzymes, membranes, and cellular fragments—represent a paradigm shift in precision oncology. These nanorobots, powered by enzyme-driven propulsion systems, are capable of traversing biological fluids, locating cancerous tissues, and releasing therapeutic agents directly at tumor sites with minimal off-target effects. This paper investigates the working mechanisms, fabrication strategies, propulsion dynamics, and tumor-targeting pathways of these systems. It also contextualizes the technology within the landscape of pre-2024 literature and evaluates their transformative potential for personalized and minimally invasive cancer treatment.
Author: Researcher
Language: English
Topic: Micro and Nano Robotics
Subfield: Condensed Matter Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6912182529
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