Formulation and Evaluation of Melt in Mouth Sildenafil Citrate Tablets by Using Super Disintegrants
Year: 2025
Type: dissertation
Abstract: New Using the solvent evaporation approach, co-processed super disintegrants were created by integrating one super disintegrant into the particle structure of another. By using the direct compression method with CCS, Kyron T-314, physical blend, and co-processed combination of both super disintegrants in varying ratios, melt-in-mouth tablets with 25 mg of sildenafil citrate each were created. When creating melt-in-mouth tablets, disintegration time is crucial. The pills with the quickest wetting times were found to have the quickest disintegration times. Compared to tablets containing CCS alone, Kyron T-314 alone, and their physical mixes, the tablets containing co-processed super disintegrants disintegrated more quickly. Key words: Sildenafil citrate, Kyron T-314, Croscarmellose sodium, Disintegrants
Author: Bhavya Paleti*, Kondetti Devi Priya, Kumavath Sravani Bai, Mohammed Ibrhim Shabrooz, Putta Somaiah, Rachamallu Rohitha Sai
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6912185154
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