Modern approaches to morphological diagnosis of pediatric brain tumors: integration of IHC and genetic testing
Year: 2025
Type: conference-paper
Abstract: This study explores the integration of immunohistochemistry (IHC) and genetic testing in the morphological diagnosis of pediatric brain tumors. Tissue samples from 102 pediatric patients aged 1–17 years were analyzed using both traditional histopathology and advanced molecular tools. Markers such as Ki-67, GFAP, OLIG2, and Synaptophysin were evaluated alongside IDH1 and BRAF V600E mutations. The combined approach significantly improved tumor classification accuracy and provided prognostic insights. The study demonstrates that incorporating IHC and genetic profiling into standard diagnostic algorithms enhances the precision of pediatric neuro-oncology diagnostics and supports the development of individualized treatment strategies.
Authors: Suxrob Tashmatov, Baxodir Magrupov
Institution: Tashkent Pediatric Medical Institute
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W6912207932
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