Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from Picralima nitida
Year: 2024
Type: article
Abstract: Eight monoterpene indole alkaloids (1–8), including one new picraline-type alkaloid, 2-hydroxyakuammiline (4) and seven known compounds: akuammigine (1), akuammine (2), akuammidine (3), akuammiline (5a), akuammiline N-oxide (5b), akuammiline (6), rhazimol (7), and alstonine (8) were isolated from the seeds of Picralima nitida. Structure elucidation was done by analysis of their MS and NMR spectroscopic data. The antiplasmodial effects of compounds 1–7 were moderate. Compound 8 showed significant effects with pXC50 of 6.3. Compounds 1 and 7 showed significant trypanocidal effects with pXC50’s of 5.1 and 5.4 respectively.
Source: Figshare
Authors: Laryea, Michael Konney, Abotsi, Kofi Mensah Wonder, Woode, Eric, Dickson, Rita Akosua, Webster, Lauren, Ekuadzi, Edmund
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6920923588
FWCI:
Cites:
Cited by:
Related to: