Longitudinal kidney outcomes in surviving COVID-19 patients in Africa: a prospective Congolese single-center cohort study
Year: 2025
Type: article
Abstract: The aim of this study was to determine kidney outcomes and associated factors in COVID-19 patients discharged from intensive care unit (ICU) in an African setting. In a prospective observational single-center cohort study, we compared the rate of decline in eGFRcr and the incidence of CKD between COVID-19 patients with and without AKI after discharge from ICU. Kidney function decline (KFD) and chronic kidney disease (CKD) during 2 years of follow-up were defined as eGFR decline ≥ 30% and eGFR less than 60 mL/min/1.73 m2 and/or the presence of proteinuria, respectively. The association between COVID-19-associated AKI (COVID-AKI) and eGFR decline after hospital discharge was assessed using mixed-effects models. Logistic regression and Cox regression were used to define factors associated with KFD and CKD. The incidence of KFD and CKD at two years of follow-up was 23% and 0.73 per 100 patient months (P-M), respectively. Patients with COVID-AKI had a greater decline in eGFR (-11.09 mL/min/1.73 m2/year [95% CI, −3.65 to-1.02]; p ˂0.001) and CKD incidence (3.11 per 100 P-M vs 0.18 per 100 P-M, p = 0.003) in the fully adjusted model controlling for comorbidities and peak creatinine level. AKI was associated with KFD (aOR: 3.46 [2.40-5.24], p = 0.001) and CKD (aHR: 3.37 [2.35-5.41], p = 0.003). KFD and CKD are common in COVID-19 survivors. AKI was associated with both KFD and CKD after ICU discharge. Kidney care after COVID-19 needs to be organized in the context of AKI.
Source: Figshare
Authors: Yannick Mayamba Nlandu, Jean-Robert Rissassi Makulo, Marie Essig, Yannick Mompango Engole, Marie-France Ingole Mboliasa, Aliocha Natuhoyila Nkodila, Vieux Momeme Mokoli, Clarisse Nsenga Nkondi, Augustin Luzayadio Longo, François Musungayi Kajingulu, Cédric Kabemba Ilunga, Chantal Vuvu Zinga, Evariste Mukendi Kadima, Justine Busanga Bukabau, Steve Mundeke Ahuka, Aimé Lumaka, Nazaire Mangani Nseka, Ernest Kiswaya Sumaili
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6921035825
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