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Imaging Techniques for the Analysis of Blood-Brain Barrier and Gliovascular Unit Dysfunction

Year: 2024

Type: article

Abstract: Proper blood-brain barrier (BBB) function is essential to maintain homeostasis keeping the central nervous system healthy. Disruption of the BBB has been described in nearly all neurological disease and injury contexts. Given the various physical and metabolic roles of the BBB and gliovascular unit (GVU), dysfunction should be assessed across multiple levels to pinpoint the exact nature of the impairment. Here we describe imaging techniques for evaluating various aspects of BBB and GVU integrity and function, tailored for use in mouse models with protocols for quantitative image analysis. These imaging techniques complement classical dye tracer experiments and reveal underlying molecular causes of BBB dysfunction.

Source: Maryland Shared Open Access Repository (USMAI Consortium)

DOI: 10.13016/m2xogo-wst6

Authors: Robel, Stefanie, Munoz-Ballester, Carmen, Heithoff, Benjamin, George, Kijana, Robel, Stefanie

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6922497487

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