Risk factors for the initial symptom of epileptic seizures in patients with glioma
Year: 2025
Type: article
Abstract: Objective To investigate the risk factors for the onset of glioma in patients with the initial symptom of epilepsy. Methods A total of 309 patients with glioma who were diagnosed and treated in our hospital from January 2016 to December 2019 were enrolled, and according to whether the initial symptom was epilepsy, they were divided into observation group with 81 patients and control group with 228 patients. A retrospective analysis was performed for general information (age, sex, smoking history, drinking history, history of chronic diseases and head trauma, extent of tumor lesion, and degree of tumor diffe-rentiation) and blood biochemical parameters (total cholesterol, triglycerides, high-density/low-density lipoprotein cholesterol, fasting blood glucose, calcium, potassium, and phosphorus), and a multivariate logistic regression analysis was used to investigate the risk factors for epileptic seizures in patients with glioma. Results Among the patients with glioma, the patients with epileptic seizures as the initial symptom accounted for 18.95%. The analysis showed that there were significant differences between the two groups in the history of drinking, epilepsy, diabetes, and head trauma, the extent of tumor lesion, the degree of tumor diffe-rentiation, and the serum levels of total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, potassium, and phosphorus (χ2=3.915-12.513,P<0.05). The multivariate logistic regression analysis showed that the history of drinking/epilepsy/head trauma, high fasting blood glucose, a large extent of tumor lesion, and a low degree of tumor differentiation were risk factors for epileptic seizures (OR=1.257-3.823,P<0.05). Conclusion The history of drinking/epilepsy/head trauma, high fasting blood glucose, a large extent of tumor lesion, and a low degree of tumor differentiation are risk factors for the initial symptom of epileptic seizures in patients with glioma. Patients with such conditions should be taken seriously during clinical diagnosis and treatment, and active prevention and treatment should be performed according to the medical advice.
Author: LI Xingchao, WANG Youfang, LI Ming, ZHOU Liangjian, LI Mingzhu, XIAO Shuai, CHE Fengyuan, ZHANG Jinling
Institution: Linyi People's Hospital
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6922800754
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