Year: 2025
Type: dissertation
Abstract: A genetic reference panel is a powerful tool for analyzing how variations in underlying genes give rise to phenotypic traits in an organism. By aligning sequenced genome assemblies, genetic reference panels allow for in-depth analysis of gene function. Previous literature has described the creation of genetic reference panels for the species Drosophila melanogaster, a ubiquitous, widely studied model organism used for genetics research. However, no genetic reference panel currently exists for Drosophila santomea, a melanogaster sister species native to the Sao Tome islands off the coast of Africa. We use assembled and aligned Drosophila santomea genomes to create the Drosophila santomea genetic reference panel. This genetic reference panel consists of fully sequenced, isolated lines of D. santomea populations derived from natural populations and inbred for at least 20 generations, ensuring genetic uniformity among individuals within each population. The Drosophila santomea genetic reference panel aims to serve as a resource for the analysis of population genomic variation and gene function and can provide broader insights into the evolutionary processes that cause genetic divergence between Drosophila species.
DOI: 10.17615/x0td-rb46
Author: Martin, Samuel
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6925146784
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