Catalytic Multi-component Coupling Reactions of Silyl Glyoxylates
Year: 2024
Type: dissertation
Abstract: Described is the development of catalytic, stereoselective reactions of silyl glyoxylates utilizing Rh(I)-catalyzed additions of aryl boronic acids. This reactivity was translated asymmetrically via additional effort from our laboratory resulting in the development of a novel tricyclo-[2.2.1.0]- ligand which provided levels of enantioinduction previously unseen within these types of systems. The value of this methodology was expanded towards three-component couplings with aryl aldehydes functioning as an electrophilic trap. Investigative efforts were also applied to improving reaction diastereoselectivity through the application of more sterically encumbered glyoxylates.
DOI: 10.17615/pmmf-yw18
Author: Turman, Nolan Clark
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6925236238
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