Work

Magnetic Particle Spectrometry of 3D cancer cell spheroids

Year: 2024

Type: article

Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have a significant role in biomedical applications such as hyperthermia therapy or magnetic particle imaging. This study investigates the loading of 3D cell spheroids made from a pancreas cell line of rats with magnetic nanoparticles. Here, we show the uptake and a homogeneous distribution of nanoparticles in spheroids, while magnetic particle spectrometry (MPS) reveals a measurable difference in the magnetic behavior of nanoparticles in aqueous solution compared to those incorporated into spheroids.

Source: International journal on magnetic particle imaging

DOI: 10.18416/ijmpi.2025.2503050

Authors: Rossa, Lea Antonia, Wei, Huimin, Lemcke, Heiko, Brandenburger, Matthias, Bakenecker, Anna C.

Institutions: Fraunhofer-Einrichtung für Individualisierte Medizintechnik, Technische Universität Darmstadt

Language: English

Topic: Characterization and Applications of Magnetic Nanoparticles

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: European Regional Development Fund