Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage.
Year: 2024
Type: article
Abstract: The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.
Source: Figshare
Authors: Panten, Jasper, Del Prete, Stefania, Cleland, James P, Saunders, Lauren M, van Riet, Job, Schneider, Anja, Ginno, Paul, Schneider, Nina, Koch, Marie-Luise, Chen, Xuqi, Gerstung, Moritz, Stegle, Oliver, Arnold, Arthur P, Turner, James MA, Heard, Edith, Odom, Duncan T
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6926433758
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