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Investigation of functionalized (2-Phenylpyridine)Pt(II) complexes for monitoring and interfering with amyloid aggregation

Year: 2024

Type: article

Abstract: Several diseases (e.g. Alzheimer’s disease (AD)) are characterized by formation of cytotoxic amyloid oligomers and fibrils. Consequently, methods to detect and monitor amyloid assemblies may offer new insight into neurodegenerative disease diagnosis and therapy. Phenylpyridine (ppy) acetylacetone (acac) coordinated square-planar Pt(II) complexes are easily prepared organometallic complexes that possess attractive photophysical properties and biocompatibilities in in vitro and in vivo settings. These properties render cyclometalated Pt(II) complexes potentially useful as luminescent bioprobes.

Source: Iowa Research Online (The University of Iowa)

DOI: 10.25820/etd.007643

Author: Li, Zhuoheng

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6927190528

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