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The role of TREM-1 in allergic airway inflammation

Year: 2025

Type: article

Abstract: Asthma affects 25 million Americans, and recent advances in treatment are effective for only a portion of severe asthma patients. TREM-1, an innate receptor that canonically amplifies inflammatory signaling in neutrophils and monocytes, plays a central role in regulating lung inflammation. It is unknown how TREM-1 contributes to allergic asthma pathology. We utilized genetic mouse models and a model of allergic airway inflammation (AAI) to investigate the effects of TREM-1 ablation on AAI disease severity, type 2 immune responses, and myeloid cell function.

Source: Iowa Research Online (The University of Iowa)

DOI: 10.25820/etd.007843

Author: Bowen, Jayden L

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6927400059

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