Sauerstoffmangel im Gehirn: Perfusion und Verfügbarkeit von A1-Adenosinrezeptoren
Year: 2025
Type: article
Abstract: In animal studies, it has been observed that the neuromodula-tor adenosine is released into the interstitial space of the brainduring hypoxia and protects the brain from oxygen deficiencyand overexertion by adjusting cerebral blood flow, metabolismand electrical activity. This study exposed 10 subjects to aninterval of 30-min hypoxia equivalent to the partial pressure ofoxygen at about 5500 m. This resulted in a significant reductionin A 1 adenosine receptor (A 1 AR) availability in the human brain,a significant increase in heart rate, and a significant slowing ofreaction speed. This is to our knowledge the first demonstra-tion in humans that acute hypoxia reduces A 1 AR availability inthe brain. This result supports the hypothesis that hypoxia-in-duced adenosine release leads to increased occupancy of theA 1 AR and can thus pave the way for future countermeasures.
Authors: Michno, Manuel, Schmitz, Jan, Foerges, Anna L., Beer, Simone, Jordan, Jens, Neumaier, Bernd, Drzezga, Alexander, Aeschbach, Daniel, Bauer, Andreas, Tank, Jens, Weis, Henning, Elmenhorst, Eva-Maria, Elmenhorst, David
Institution: Forschungszentrum Jülich
Language: English
Topic: High Altitude and Hypoxia
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W6927417921
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