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Emerging Insights into the Pathogenic Mechanisms of Myokines and Hepatokines in Muscle-liver Crosstalk: Implications for Non-alcoholic Fatty Liver Disease and Sarcopenia

Year: 2024

Type: article

Abstract: Non-alcoholic fatty liver disease (NAFLD) and sarcopenia are prevalent metabolic disorders in middle-aged and elderly populations, with overlapping pathogenic mechanisms. The liver and skeletal muscle secrete hepatokines and myokines, which play crucial roles in maintaining energy homeostasis by activating metabolic signaling pathways and mediating crosstalk in the muscleliver axis. This review explores the specific mechanisms by which myokines and hepatokines contribute to the pathogenesis of NAFLD and sarcopenia, aiming to elucidate the regulatory network between the liver and skeletal muscle.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.3969/j.issn.1674-7593.2024.05.001

Authors: Ziwei Gu, Yuxing Zhao, Kexiang Zhao, Qian Xiao

Institution: The Affiliated Yongchuan Hospital of Chongqing Medical University

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6928978976

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