Micro Engineering To Create Bio Mimic Living Systems With Organ-On-A-Chip
Year: 2024
Type: article
Abstract: Key components of real organs, such as essential microarchitecture, spatiotemporal cell-cell interactions, and extracellular microenvironments, are faithfully created by “organ-on-a-chip” systems, which combine microengineering, microfluidic technology, and biomimetic concept. a wide range of applications, including the creation of human in vitro models for healthy or diseased organs, can benefit greatly from this innovative platform’s multiorgan integration, which recapitulates organ-level structures and functions potentially replacing animal testing, helping drug development with toxicity screening and target identification, and facilitating the study of basic mechanisms in disease etiology and organogenesis.. A review is conducted on the latest developments in innovative designs and instances of developing organ-on-a-chip platforms there is a discussion of how this new technology may be used to comprehend human physiology, including precise spatiotemporal controls over mechanical, chemical, and electrical signals for these proof-of-concept investigations, the present obstacles and necessary future paths are also emphasized
Author: Sabafarin H. Shaikh* Sagar Patki, Rohit Karad, Niket Pradhan, Mohammad Sufiyan, Sushmita Chavan
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6930329595
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