Formulation and Evaluation of Nevarapine Extended Release Matrix Tablets
Year: 2024
Type: article
Abstract: Nevarapine is a non-nucleoside reverse transcriptase inhibitors (NNRTI) drug which is used in treatment in in Human Immunodeficiency Virus type 1 (HIV) infection. The present study is to develop a pharmaceutical stable, cost, effective, pharmaceutically equivalent, and quality improved formulation of NEVARAPINE Extended release Tablets. To achieve this goal various prototype formulation trials will be taken and evaluated with respect to the various quality control test such as dissolution, assay, acidresistance. The formula will be finalized by comparing the dissolution profile with that of the marketed VIRAMUNE XR tablets. In this study NEVIRAPINE Extended release Tablets were prepared by using hydrophobic polymers. 12 formulations of Extended release Tablets of nevarapine were developed by using Microcrystalline Cellulose as diluent andMagnesium Streate as lubricant in different proportion. The formulation F3 was found to be best of all the formulation showing drug release matching the innovator product. Hence it is considered as optimised Formulation. Keywords: -Nevarapine, extended release, hydrophobic polymers, ethyl cellulose, magnesium sterate.
Authors: Nadia*, Prabhakar Reddy V
Institution: Palamuru University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6930331330
FWCI:
Cites:
Cited by:
Related to: