Co-Crystals in Enhancing Drug Solubility and Stability: A Comprehensive Review
Year: 2025
Type: article
Abstract: Co-crystals are solid-state complexes formed by an active pharmaceutical ingredient (API) and a co-former in a defined stoichiometric ratio. They offer a promising strategy to address the challenges of poor solubility and stability in pharmaceutical formulations. This review delves into the mechanisms by which co-crystals improve drug solubility, enhance stability, and optimize bioavailability. We explore the different techniques used in co-crystal formation, their characterization, advantages over traditional formulations, and challenges in commercialization and regulatory approval. Additionally, we review case studies highlighting successful co-crystal applications and discuss future directions for research in the field. The insights provided in this paper offer a deeper understanding of co-crystal technology and its potential to revolutionize the pharmaceutical industry.
Author: Vaishnavi Adsul*1, Dr. Swapnil phade1, Pratik Bhabad2
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6930349028
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