In Vitro Evaluation of Antifungal Activity of Series of 2-Phenyl-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-4H-4-chromenone Compounds
Year: 2024
Type: article
Abstract: A new series of 2-phenyl-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-4H-4-chromenone 1(a-j) has been synthesized by the reaction of 3(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)-2-phenyl-4H-4-chromenone with a variety of phenacyl bromides in ethanol under reflux. The compound with the 4-bromophenyl (1g) greatest anti A. niger action, while compound (1a) had the least. Except for 1a and 1i, these compounds also shown efficacy against Candida albicans. While others showed moderate to good action, the compound containing the 4-methoxyphenyl (1c) good activity against C. albicans.
Author: G. Nageswara Rao
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6930436509
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