Formulation and Evaluation of Oral Disintegrating Tablets Containing Clove Powder as an Analgesic for Toothache
Year: 2025
Type: article
Abstract: Objective: This study aims to formulate and evaluate oral disintegrating tablets (ODTs) incorporating clove powder as an analgesic for toothache. Clove is rich in eugenol and has shown analgesic activity, antimicrobial, and anti-inflammatory, and has been used as a traditional remedy for tooth pain. This study included Clove powder in ODTs to guarantee quick dissolving and timely toothache treatment for patients. The difficulty, though, is in creating a dose form that is both efficient and patient-friendly. Among the many benefits of oral disintegrating pills are their quick onset of action and convenience of administration without water. The active substance in the tablets was clove powder, and crosprovidone was used as a super-disintegrants. Methodology: Direct compression was used to prepare oral disintegrating tablets containing clove powder as active Pharmaceutical Ingredients and crospovidone, mannitol, aspartame, magnesium stearate, and talc as excipients. Evaluation parameters were evaluated, including thickness, disintegration time, weight variation, hardness, and friability. Pre-compression assessments were also carried out such as angle of repose, bulk, and tapped density. Results: The results demonstrate that clove powder might be successfully added to oral disintegration tablets and might be a good substitute for treating toothaches by offering immediate, localized pain relief in a handy, simple-to-give dosage form. Additionally, the study indicates that the prepared tablets may be a good substitute for treating conditions where Clove's therapeutic qualities are advantageous.
Author: Rohit Khandare*, Sarika Nikam
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6930489135
FWCI:
Cites:
Cited by:
Related to: