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Identificação da Dipirona em Medicamentos de Referência e Genéricos usando Espectroscopia Raman

Year: 2024

Type: article

Abstract: The present study aims to use Raman spectroscopy to identifythe peaks referring to the active pharmaceutical ingredient (IAF) dipyrone in reference medicines (Novalgina) and generics (EMS and Medley) in 500 mg tablets and 500 mg drop solutions. mg/mL, analyzing tablet samples both inside and outside the blisters. The results indicated that Raman spectroscopy proved to be effective in identifying IAF in drop and tablet formulations, even though blisters, confirming the presence of the active ingredient as declared on the labels and the invariability of the formulation of generic medicines compared to the reference, reinforcing the quality and bioequivalence of the generics analyzed. Keywords: Raman spectroscopy; dipyrone; quality control;identification of active pharmaceutical ingredient.

Source: Anais do Encontro Nacional de Pós Graduação

DOI: 10.5281/zenodo.14200903

Authors: Kiyotani, Rafael, Silveira, Bruno, Guimarães, Luciana, Silva, Alexandre, Rocco, Débora, Silveira Jr, Landulfo

Institutions: Universidade Santa Cecília, Universidade Federal de São Paulo, Anhembi Morumbi University

Language: English

Topic: Pharmaceutical Quality and Counterfeiting

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W6930493833

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