Clinical Efficacy of Laparoscopy in the Treatment of Early Endometrial Cancer and Its Impact on Patients' Sexual Function
Year: 2024
Type: article
Abstract: The study aims to rigorously assess the clinical efficacy of laparoscopic surgery ascompared to traditional laparotomy for the treatment of early-stage endometrialcancer, with a specialized focus on its subsequent impact on patients' sexualfunctionality. A retrospective analysis was executed, involving 76 patients diagnosedwith early-stage endometrial cancer and treated at our institution between February2021 and February 2022. Patients were bifurcated into two cohorts: one subjected tolaparotomy (n=38), and the other to laparoscopic surgery (n=38). The study undertooka comprehensive analysis of perioperative metrics, postoperative complications, andboth pre- and postoperative evaluations of sexual function, nutritional markers (serumtotal protein [TP], albumin [ALB], and prealbumin [PAB]), and inflammatory indices(C-reactive protein [CRP], tumor necrosis factor-α [TNF-α], and interleukin-6 [IL-6]).Laparoscopic intervention manifested a statistically significant reduction in operativeduration, intraoperative hemorrhage, time to postoperative flatus, and overallhospitalization period compared to the laparotomy group (P<0.05). The quantity oflymph nodes excised was statistically equivalent between the two modalities (P>0.05).Sexual function parameters remained relatively stable postoperatively in the laparoscopic cohort, in stark contrast to a notable decline in the laparotomy group(P<0.05). Additionally, the laparoscopic approach demonstrated superiorpostoperative nutritional and inflammatory profiles (P<0.05) and a markedly lowercomplication incidence of 13.16% vis-à-vis 34.19% in the laparotomy arm (P<0.05).Laparoscopic surgery emerges as a less invasive yet equally efficacious modality forthe treatment of early-stage endometrial cancer, delivering comparablelymphadenectomy outcomes to laparotomy. The approach not only mitigates the rateof postoperative complications but also exerts a preservative effect on sexual functionand engenders a more favorable postoperative inflammatory and nutritional milieu.
Author: Shan Muzamail, Sadia Jabeen, Urwah Rasool, Anoshka Shahbaz, Zainab Basharat, Sadaf Rafiq, Sumeet Dayyan, Anam Malik, Maira Eram, Muhammad Umair
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6930543258
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