Work

Gold Nanostar-Decorated Electrospun Nanofibers Enable On-Demand Drug Delivery

Year: 2025

Type: article

Abstract: This study explores the development of a photo-responsive bicomponent electrospun platform and its drug delivery capabilities. This platform is composed of two polymers of poly(lactide-co-glycolide) (PLGA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). Then, the platform is decorated with plasmonic gold nanostars (Au NSs) that are capable of on-demand drug release. Using Rhodamine-B (RhB) as a model drug, the drug release behavior of the bi-polymer system was compared versus homopolymer fibers. The RhB was incorporated in the PLGA part of the platform, which provided a more sustained drug release, both in the absence and presence of near-infrared (NIR) irradiation. Under NIR exposure, thermal imaging reveals a notable increase in surface temperature, facilitating enhanced drug release. Furthermore, the platform demonstrates on-demand drug release upon multiple NIR irradiation cycles. This platform offers a promising approach for stimuli-responsive drug delivery, making it a strong candidate for on-demand therapy applications.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.14905597

Author: Pierini, Filippo

Institution: Institute of Fundamental Technological Research

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Narodowe Centrum Nauki, Narodowa Agencja Wymiany Akademickiej