Advances in The Chemistry of Pro-Drugs for Enhanced Drug Delivery Systems
Year: 2025
Type: article
Abstract: The pharmaceutical industry faces significant challenges in drug development, particularly related to poor bioavailability, low solubility, and inadequate targeting of drugs to specific tissues or organs. Pro-drugs, chemically modified drug molecules that are pharmacologically inactive until converted into their active form, offer a promising solution to these problems. By modifying the chemical properties of a drug, pro-drugs can improve absorption, distribution, metabolism, and excretion (ADME) characteristics. Additionally, pro-drug design allows for targeted drug delivery, reducing side effects and improving therapeutic outcomes. This review explores the recent advances in pro-drug chemistry, focusing on novel activation mechanisms, pro-drug strategies for specific drug delivery, and the integration of nanotechnology. Emerging trends in personalized medicine and challenges in the field are also discussed, providing a comprehensive overview of the current state of pro-drug-based drug delivery systems.
Author: Sandesh Shelke*, Vedant Shivange, Pratik Bhabad
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6930637024
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