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Impact of Lipid Nanoparticle Size and Charge on Lymph Node Transport and Distribution in Microfluidic Mixing

Year: 2025

Type: article

Abstract: Lipid nanoparticles (LNPs) are crucial vehicles for drug delivery, particularly in vaccines and gene therapies. However, their transport dynamics within lymphatic systems remain poorly understood. This study investigates how LNP size and surface charge influence their transport and distribution to lymph nodes, using a microfluidic mixing platform that mimics interstitial flow. LNPs of varying diameters (30–150 nm) and zeta potentials (-30 mV to +30 mV) were synthesized and characterized. Microfluidic assays revealed size- and charge-dependent variations in lymph node targeting efficiency, with smaller, slightly negative LNPs demonstrating superior transport and retention. These findings offer critical insights for the rational design of LNPs for targeted lymphatic delivery.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.15230713

Author: Ashvini Patmase*1, Mahesh Kurhe1, Ankit Muley1, Pratiksha Rajguru2, Sahil Gadhave3, Snehal Daud4

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6930639893

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