Can the Jonckheere trend test be recommended to evaluate genetic association studies?
Year: 2024
Type: article
Abstract: In a recent paper by Manning et al. (Plos One 2024) entitled A nonparametric alternative to the Cochran-Armitage trend test in genetic case-control association studies: The Jonckheere-Terpstra trend test, the Jonck-heere trend test was recommended for case-control studies in genetic association studies. This proposalis critically questioned here. Instead, maximum tests over the three mode of inheritances: additive,recessive and dominant are propoes: i) for case-control studies the max-test for multiple contrasts, ii) for studies with approximately Gaussian distributed traits the max-test based on regression models using the multiple marginal models approach and iii) for non-normal traits the non-parametric multiple contrast test can be recommended.
Author: Hothorn, Ludwig A.
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6930649833
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