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Acute Rheumatic Fever A brief overview of its pathogenesis, prevalence, epidemiology

Year: 2025

Type: article

Abstract: Acute Rheumatic Fever (ARF) is an autoimmune sequela of pharyngeal infection with group A β-hemolytic streptococcus (GAS), primarily affecting children and adolescents. ARF continues to be a major public health concern in developing countries and among underserved populations in high-income nations. The disease manifests with a variety of symptoms including carditis, arthritis, chorea, and dermatologic signs. ARF may progress to chronic rheumatic heart disease (RHD), a leading cause of cardiovascular morbidity and mortality in young adults. This article provides a comprehensive overview of the etiology, immunopathogenesis, clinical manifestations, diagnostic criteria, therapeutic interventions, and preventive strategies. Emphasis is placed on early recognition, evidence-based management, and long-term prophylaxis to curb recurrence and associated complications.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.15306453

Authors: Jazgul, Abjamilova, Frazia, Shakira Khan

Institution: Osh State University

Language: English

Topic: Streptococcal Infections and Treatments

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W6930652512

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