Enhancing Tympanoplasty Outcomes: Evaluating the Effectiveness of Platelet-Rich Plasma in Type 1 Tympanoplasty with Temporalis Fascia Grafts
Year: 2024
Type: article
Abstract: Objective: This study evaluated the impact of Platelet-Rich Plasma (PRP) on the outcomes of Type 1 tympanoplasty using temporalis fascia grafts. Methodology: This study utilized a cohort prospective randomized controlled trial (RCT) design over 24 months at a tertiary care facility in Northern India to assess the effectiveness of Platelet-Rich Plasma (PRP) in Type 1 Tympanoplasty with temporalis fascia grafts. A total of sixty-five patients with chronic otitis media were randomly assigned to either the PRP group (n=32) or the control group (n=33). The randomization process ensured detached group allocation for evaluating the impact of PRP on surgical outcomes. Result: The study compared demographic and clinical factors in CSOM patients. Group 1 had fewer individuals aged 18-30 and more non-working individuals than Group 2. PRP treatment (Group 2) showed significantly higher graft uptake (90.6% vs. 69.7%, p=0.032). Group A experienced greater hearing improvement (15.06 dB vs. 14.93 dB, p=0.03) and a larger reduction in air-bone gap (24.09 ± 7.54 dB vs. 22.8 ± 8.14 dB). Follow-up attendance was high across both groups, with Group B achieving 100% attendance at all intervals. Conclusion: In conclusion, Platelet-Rich Plasma (PRP) enhances graft uptake and hearing outcomes in Type 1 tympanoplasty, as indicated by improved air-bone gap and success rates. However, the overall impact on graft uptake remains uncertain, warranting further research with optimized PRP protocols and larger, standardized trials to confirm its effectiveness.
Authors: Simmi Hasan, Seema Monga, Deepti Agarwal, Shahid Rasool, Juhaina Iqbal
Institution: Jamia Hamdard
Language: English
Topic: Ear Surgery and Otitis Media
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6930690639
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