Year: 2024
Type: article
Abstract: Morphea, or localized scleroderma, is a rare inflammatory connective tissue disorder characterized by skin thickening and fibrosis. This review provides an overview of morphea, including its epidemiology, pathogenesis, clinical types, diagnosis, and treatment options. Morphea predominantly affects children and women, with peaks in early childhood and the fifth decade of life. The disease involves genetic, environmental, and immune factors, leading to increased collagen production. Clinical forms include limited, generalized, linear, mixed, and pansclerotic types. Diagnosis is clinical, supported by histopathology and imaging. Treatment is individualized, involving topical therapies (corticosteroids, tacrolimus), systemic therapies (methotrexate, corticosteroids), and phototherapy (UVA, PUVA). Emerging therapies targeting specific pathways show promise. In children, early aggressive treatment is crucial to prevent complications. Postirradiation morphea and variants like keloid morphea require accurate diagnosis for appropriate management. Phototherapy, particularly low-dose UVA, is effective. Early diagnosis and tailored treatment are essential for managing morphea and preventing long-term complications.
Authors: Gogoi Ipsita, Roy Joydeep, Gupta Bhaskar, Paul Arup, Kar Shromona
Institution: Silchar Medical College and Hospital
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6930727476
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