Serotonin dysfunction in autism spectrum disorder: A neurological perspective
Year: 2025
Type: article
Abstract: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social interaction, communication difficulties, and repetitive behaviours. Emerging evidence suggests that serotonin (5-hydroxytryptamine, 5-HT) plays a pivotal role in ASD pathophysiology. Serotonin's widespread influence on neurodevelopmental processes, including neurogenesis, synaptogenesis, and neural circuit formation, underscores its significance in ASD research. Hyperserotonemia, a condition marked by elevated blood serotonin levels, has been identified as the first biomarker of ASD, affecting approximately 30% of individuals with the disorder. Genetic studies implicate serotonin transporter (SERT) gene variations, such as the Ala56 variant, in ASD-associated behaviouralabnormalities. Functional imaging and biochemical studies reveal disruptions in serotonin synthesis, receptor binding, and transporter activity in autistic individuals.
Author: Devika.S ,Serman.S ,Kavitha.P ,Manojkumar ,Sujithkumar.M ,Yamuna.S ,Vasanth.R , Tamizharasan.K ,Pavidharani.C
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6930756994
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