A Review on Gas Chromatography: Techniques, Methodologies, and Applications-Implications to Pharmaceutical Research
Year: 2025
Type: article
Abstract: Gas chromatography (GC) is a powerful analytical technique used for the separation, identification, and quantification of volatile and semi-volatile compounds. This review explores the fundamental principles of GC, focusing on its working mechanism, stationary phases, column selection, operational conditions, sample introduction techniques, detection devices, and detection processes. Additionally, it covers qualitative and quantitative methods, applications in drug substance development, sample preparation techniques, derivatization methods, and chiral gas chromatographic applications. The article concludes with a discussion on recent advancements and future prospects of GC in pharmaceutical analysis.
Author: Deshoju Srinu*, B. Jainendra Kumar
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6930759600
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