Development And Validation of RP-HPLC Method for Simultaneous Estimation of Dapagliflozin Propanediol Monohydrate and Telmisartan in Synthetic Mixture
Year: 2025
Type: article
Abstract: Dapagliflozin and Telmisartan belongs to the anti-diabetic drugs. Development and validation of Simple, Precise and Accurate RP-HPLC method for estimation of Dapagliflozin and Telmisartan in solid dosage form. The validation of this method was achieved as per ICH Q2 (R2) guidelines with the optimized experimental conditions. To achieve the proposed method on Intsil C18 column (250 mm x 4.6 mm, 5 µm) column as Stationary Phase and run time was 10 min. The Mobile Phase consists of Acetonitrile: Methanol (75:25v/v). UV detection was carried out at 272nm. Linearity co-relation co-efficient found is 0.999. The method was validated by determining its accuracy, linearity and precision. The proposed method is simple, precise, economical and hence can be applied for routine quality control of esmolol hydrochloride in semi solid dosage form.
Author: Brinda Jodhani*, Dhirendra Kumar Tarai, Khyati Bhupta, Dr. Santosh Kirtane
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W6930783249
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