Rare cause of organic hypoglycaemia: association of nesidioblastosis, focal nesidiodysplasia and multiple pancreatic micro-adenomas.
Year: 2024
Type: article
Abstract: The etiological diagnosis of hypoglycemia in the non-diabetic patient is complex and includes a variety of diseases, including endogenous hyperinsulinism caused by functional β-cell disorders, the latter also known as nesidioblastosis or non-insulinoma pancreatogenic hypoglycemia syndrome (NIPHS). We report the case of a 62-year-old patient, not known to be diabetic, hypertensive on triple therapy, presenting with hypoglycemic episodes reaching 0.34 g/l for 2 years. Biological tests showed insulinemia at 676 pmol/l (norms 18-173pmol/l), C-peptide at 2980 pmol/l (norms 300-1400pmol/l). An octreoscan revealed a focus of radiotracer fixation in the head of the pancreas. The patient underwent 2 operations with persistent hypoglycemia; the combination of diasoxide 300mg/d and lanreotide 120mg/3 weeks led to the disappearance of hypoglycemia and a favorable outcome.
Authors: Fatima Ezzahra, Mennani, Meryame, Alahyane, Sara, Ijdda, Sana, Rafi, Ghizlane, Elmghari, Nawal El, Ansari, Chafiaa, Benallal, Hanane, Rais
Institution: Centre Hospitalier Universitaire Mohammed VI
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W6930828691
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